America, 1899. It is the beginning of the end of the Wild West era, with lawmen hunting down the last remaining outlaw gangs. Those who do not surrender or succumb are simply exterminated.

When a robbery goes terribly wrong in the town of Blackwater, Arthur Morgan and the Van der Linde gang are forced to flee. With federal agents and the nation's best bounty hunters pursuing them, the gang must rob, steal, and fight their way across the rugged heartland of America in order to survive.

As deepening internal divisions threaten to tear the gang apart, Arthur must choose between his own ideals and loyalty to the gang that raised him.